Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6451175 | 0.81 | GPR119 (0.43) | HPGDGPR119RECQLEPHX1KMT2A | |
| SCHEMBL12820311 | 0.80 | HPGD (0.53) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL6450758 | 0.79 | GPR119 (0.43) | HPGDGPR119RECQLEPHX1STS | |
| SCHEMBL15203221 | 0.79 | HPGD (0.51) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL31586656 | 0.78 | HPGD (0.50) | HPGDGPR119RECQLEPHX1KMT2A | |
| SCHEMBL29059714 | 0.78 | HPGD (0.50) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL311155 | 0.77 | HPGD (0.55) | HPGDGPR119RECQLEPHX1KMT2A | |
| SCHEMBL4052689 | 0.77 | HPGD (0.55) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL12376562 | 0.77 | HPGD (0.49) | HPGDGPR119RECQLEPHX1USP2 | |
| SCHEMBL6456079 | 0.77 | HPGD (0.49) | HPGDGPR119RECQLEPHX1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877321-A | NEUROKININ RECEPTOR | SANOFI (FR) | 1999-03-02 | — | — | US | disclosed |
| US-5446052-A | Used for treatment of substance p-and neurokinin-dependent pathology such as analgesia and inflmmation | SANOFI (FR) | 1995-08-29 | — | — | US | disclosed |
| US-5300648-A | Analgesics, antiinflammatory agents | SOCIETE ANONYME: ELF SANOFI (FR) | 1994-04-05 | — | — | US | disclosed |
| EP-0512902-A1 | Dialkyleneperidino compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |