⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22771576 | 0.97 | — | — | |
| Propane SCHEMBL8097208 | 0.94 | NOS1 (0.32) | — | |
| SCHEMBL387597 | 0.78 | — | — | |
| SCHEMBL798172 | 0.77 | KMT2A (0.62) | — | |
| SCHEMBL20879345 | 0.77 | KMT2A (0.62) | — | |
| SCHEMBL794656 | 0.77 | KMT2A (0.62) | — | |
| SCHEMBL433370 | 0.76 | KMT2A (0.35) | — | |
| SCHEMBL3951138 | 0.75 | KMT2A (0.67) | — | |
| SCHEMBL8461809 | 0.75 | KMT2A (0.67) | — | |
| SCHEMBL18927543 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067638-A1 | IMIDAZO[1,2-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-A]PYRIDINE DERIVATIVES AS TLR9 INHIBITORS FOR THE TREATMENT OF FIBROSIS | BRISTOL MYERS SQUIBB CO (US) | 2024-02-29 | — | — | US | disclosed |
| US-20230295122-A1 | 1H-BENZO[D]IMIDAZOLE DERIVATIVES AS TLR9 INHIBITORS FOR THE TREATMENT OF FIBROSIS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-21 | — | — | US | disclosed |
| WO-2022266765-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY PHENYL COMPOUNDS | MCMASTER UNIVERSITY (CA) | 2022-12-29 | — | — | WO | disclosed |
| WO-2021237371-A1 | PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS | MCMASTER UNIVERSITY (CA) | 2021-12-02 | — | — | WO | disclosed |
| WO-2020161663-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2020-08-13 | — | — | WO | disclosed |
| EP-3615535-A1 | 9-(2-OXACYCLOALKYL)-9H-PURINE-2,6-DIAMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SKIN DISORDERS | Univerzita Palackého v Olomouci (CZ) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018196893-A1 | 9-(2-OXACYCLOALKYL)-9H-PURINE-2,6-DIAMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SKIN DISORDERS | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2018-11-01 | — | — | WO | disclosed |
| US-20160229849-A1 | QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS | PRINCIPIA BIOPHARMA INC. | 2016-08-11 | — | — | US | disclosed |
| US-20140271765-A1 | METHODS AND DEVICE FOR TREATING OPIOID ADDICTION | TITAN PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-8772327-B2 | Phenylpropionic acid derivative and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2014-07-08 | — | — | US | disclosed |
| US-7005165-B2 | Photosensitive polyimides for optical alignment of liquid crystals | ELSICON, INC. (US) | 2006-02-28 | — | — | US | disclosed |
| EP-1355971-A4 | PHOTOSENSITIVE POLYIMIDES FOR OPTICAL ALIGNMENT OF LIQUID CRYSTALS | ELSICON INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-1355971-A1 | PHOTOSENSITIVE POLYIMIDES FOR OPTICAL ALIGNMENT OF LIQUID CRYSTALS | Elsicon, Inc. (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002050165-A1 | PHOTOSENSITIVE POLYIMIDES FOR OPTICAL ALIGNMENT OF LIQUID CRYSTALS | ELSICON, INC. (US) | 2002-06-27 | — | — | WO | disclosed |
| US-20010046570-A1 | Photosensitive polyimides for optical alignment of liquid crystals | ELSICON, INC. | 2001-11-29 | — | — | US | disclosed |
| US-6127388-A | Azetidine, pyrrolidine and piperidine derivatives as 5-HT1D receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| US-5998440-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARPE & DOHME LTD. (GB) | 1999-12-07 | — | — | US | disclosed |
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |
| EP-0804434-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004274-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-15 | — | — | WO | disclosed |