SCHEMBL8433228

SCHEMBL8433228

CCc1cccc(C)c1N(Cn1cccn1)C(=O)CCl

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TP53 P04637 5/20 0.59
TDP1 Q9NUW8 3/20 0.59
ALDH1A1 P00352 3/20 0.59
CYP3A4 P08684 1/20 0.59
NR1I2 O75469 1/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
POLB P06746 2/20 0.40
NLRP3 Q96P20 1/20 0.39
TSHR P16473 2/20 0.38
KDM4E B2RXH2 1/20 0.37
HPGD P15428 1/20 0.37
HSD17B10 Q99714 1/20 0.37
LMNA P02545 1/20 0.35
THRB P10828 1/20 0.35
OPRM1 P35372 1/20 0.34
ELANE P08246 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9367287 0.93 TP53 (0.56) TP53TDP1ALDH1A1CYP3A4NR1I2
Metazachlor SCHEMBL4896537 0.93 TP53 (0.48) TP53TDP1ALDH1A1CYP3A4NR1I2
Metazachlor SCHEMBL55016 0.93 TP53 (0.48) TP53TDP1ALDH1A1CYP3A4NR1I2
Metazachlor SCHEMBL9576104 0.92 TP53 (0.72) TP53TDP1ALDH1A1CYP3A4NR1I2
Metazachlor SCHEMBL14719740 0.88 ALDH1A1 (0.44) TP53TDP1ALDH1A1CYP3A4NR1I2
SCHEMBL11171392 0.88 TP53 (0.44) TP53TDP1ALDH1A1CYP3A4MEN1
Metazachlor SCHEMBL15109905 0.87 TP53 (0.44) TP53TDP1ALDH1A1CYP3A4NR1I2
SCHEMBL11031826 0.86 TP53 (0.44) TP53TDP1ALDH1A1CYP3A4MEN1
Pretilachlor SCHEMBL9509735 0.86 NR1I2 (0.67) TP53TDP1ALDH1A1CYP3A4NR1I2
SCHEMBL10731615 0.86 TP53 (0.46) TP53TDP1ALDH1A1CYP3A4NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0365484-B1 SULFAMOYL PHENYL UREAS CIBA-GEIGY AG (CH) 1993-01-07 EP claimed
US-5108482-A Protect crep plant against phytotoxic action of herbicide; plant growth regulator CIBA-GEIGY CORPORATION (US) 1992-04-28 US claimed
EP-0397602-A1 N-phenylpyrrolidines CIBA-GEIGY AG (CH) 1990-11-14 EP claimed
EP-0365484-A1 Sulfamoyl phenyl ureas CIBA-GEIGY AG (CH) 1990-04-25 EP claimed
EP-0357557-A2 Synergistic mixture CIBA-GEIGY AG (CH) 1990-03-07 EP claimed
EP-0236268-A1 Plant protection by means of N-halogenoacetyl isoquinolines against herbicidal halogen acetanilides CIBA-GEIGY AG (CH) 1987-09-09 EP claimed
US-4565565-A Dichloroacetamides, herbicides containing acetanilides as herbicidal active ingredients and the dichloroacetamides as antagonists, and the use of these herbicides in controlling undesired plant growth BASF AKTIENGESELLSCHAFT (DE) 1986-01-21 US claimed
US-5958835-A Surfactant compositions NOVARTIS CORPORATION (FORMERLY CIBA-GEIGY CORPORATION) (US) 1999-09-28 US disclosed
US-5731266-A Herbicidal compositions comprising diamino-1,3,5-triazine and chloroacetanilide herbicides and a surfactant system CIBA-GEIGY CORPORATION (US) 1998-03-24 US disclosed
EP-0378508-B1 Antidotes to modify the resistance of cultivated plants to agrochemical agents CIBA GEIGY AG (CH) 1995-03-01 EP disclosed
US-5215570-A Plant safening agents CIBA-GEIGY CORPORATION (US) 1993-06-01 US disclosed
EP-0365484-B1 SULFAMOYL PHENYL UREAS CIBA-GEIGY AG (CH) 1993-01-07 EP disclosed
US-5175289-A Antidotes for protecting cultivated plants from the phytotoxic action of herbicides CIBA-GEIGY CORPORATION (US) 1992-12-29 US disclosed
EP-0027915-A1 Herbicidal agents based on diphenyl ethers and benzothiadiazinone dioxides or pyridinothiadiazinone dioxides, and their use BASF Aktiengesellschaft (DE) 1981-05-06 EP disclosed
US-4249935-A Herbicidal agents BASF AKTIENGESELLSCHAFT (DE) 1981-02-10 US disclosed
EP-0019171-A1 Herbicidal agent on the basis of N-azolyl-methyl-halogenacetanilides and cyclohexane-1,3-dione derivatives, and its use in combating undesired plant growth BASF Aktiengesellschaft (DE) 1980-11-26 EP disclosed
EP-0009091-A1 Process for selectively combating undesired plant growth with herbicidal agents comprising acetanilides and N-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine BASF Aktiengesellschaft (DE) 1980-04-02 EP disclosed
EP-0008649-A1 Herbicidal agents comprising acetanilides and N-isopropyl-N-propargyl-dichloracetamide and process for selectively combating undesired plant growth BASF Aktiengesellschaft (DE) 1980-03-19 EP disclosed
EP-0007575-A1 Herbicidal compositions based on acetanilides and their use in combating undesired plant growth BASF Aktiengesellschaft (DE) 1980-02-06 EP disclosed
EP-0007588-A1 Tetrahydro-1,3-oxazines, herbicidal compositions containing acetanilides as herbicidal agents and said tetrahydro-1,3-oxazines as antagonistic agents, and their use for combating undesired plant growth BASF Aktiengesellschaft (DE) 1980-02-06 EP disclosed