Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255171 | 0.74 | CYP2D6 (0.56) | CYP2D6ALDH1A1POLBKDM4ENPC1 | |
| SCHEMBL7100333 | 0.74 | CYP2D6 (0.46) | CYP2D6ALDH1A1POLBKDM4ENPC1 | |
| SCHEMBL29224277 | 0.73 | KDM4E (0.47) | CYP2D6ALDH1A1POLBKDM4EUSP2 | |
| SCHEMBL1919199 | 0.72 | CYP2D6 (0.50) | CYP2D6ALDH1A1POLBKDM4ENPC1 | |
| SCHEMBL1777591 | 0.72 | ALDH1A1 (0.48) | CYP2D6ALDH1A1POLBKDM4EUSP2 | |
| SCHEMBL4056985 | 0.71 | ALDH1A1 (0.42) | CYP2D6ALDH1A1POLBKDM4EUSP2 | |
| SCHEMBL28392032 | 0.70 | KDM4E (0.48) | CYP2D6ALDH1A1POLBKDM4EUSP2 | |
| SCHEMBL6673706 | 0.70 | POLB (0.46) | CYP2D6ALDH1A1POLBKDM4ENPC1 | |
| SCHEMBL10412697 | 0.69 | KDM4E (0.47) | CYP2D6ALDH1A1POLBKDM4ENPC1 | |
| SCHEMBL16904245 | 0.68 | ALDH1A1 (0.40) | CYP2D6ALDH1A1POLBKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908937-A | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives | SCHERING-PLOUGH LTD. (CH) | 1999-06-01 | — | — | US | disclosed |