Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8435334 | 0.99 | IDH1 (0.33) | IDH1ABCB1ABCG2ALDH1A1GAA | |
| SCHEMBL8433420 | 0.81 | IDH1 (0.42) | IDH1ALDH1A1NPC1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8434597 | 0.80 | IDH1 (0.41) | IDH1ALDH1A1NPC1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8495697 | 0.77 | RAB9A (0.44) | IDH1LMNANPC1RAB9AL3MBTL1 | |
| SCHEMBL8432982 | 0.75 | TAAR1 (0.45) | LMNANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8438749 | 0.75 | TSHR (0.51) | ALDH1A1LMNAL3MBTL1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL8435752 | 0.75 | TAAR1 (0.44) | LMNANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL8433686 | 0.74 | PTGS1 (0.34) | IDH1 | |
| SCHEMBL8438545 | 0.74 | SMN1; SMN2 (0.49) | ALDH1A1LMNANPC1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8437492 | 0.74 | TSHR (0.50) | ALDH1A1GAALMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |