Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 13/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8438269 | 0.99 | ERBB2 (0.36) | ERBB2NPC1GLARAB9AL3MBTL1 | |
| SCHEMBL8437448 | 0.85 | RAB9A (0.46) | NPC1GLARAB9AL3MBTL1 | |
| SCHEMBL8434221 | 0.75 | NOS3 (0.43) | — | |
| SCHEMBL8434579 | 0.74 | HDAC4 (0.39) | — | |
| Hydrochloric Acid SCHEMBL8438947 | 0.73 | HDAC4 (0.38) | — | |
| SCHEMBL8433630 | 0.72 | TRPV1 (0.36) | ERBB2PTGS1NQO2 | |
| Hydrochloric Acid SCHEMBL8438272 | 0.71 | TRPV1 (0.36) | ERBB2PTGS1NQO2 | |
| Hydrochloric Acid SCHEMBL8438263 | 0.71 | TRPV1 (0.36) | ERBB2PTGS1NQO2 | |
| Hydrochloric Acid SCHEMBL8435748 | 0.69 | HTR2A (0.46) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL8435799 | 0.67 | HDAC4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |