Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8433718 | 1.00 | CASP3 (0.41) | CASP3SENP7NPC1HPGDMEN1 | |
| Hydrochloric Acid SCHEMBL8434946 | 0.99 | CASP3 (0.40) | CASP3SENP7NPC1HPGDMEN1 | |
| Hydrochloric Acid SCHEMBL8434955 | 0.99 | CASP3 (0.40) | CASP3SENP7NPC1HPGDMEN1 | |
| SCHEMBL8437447 | 0.85 | RAB9A (0.47) | CASP3SENP7NPC1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8433464 | 0.84 | RAB9A (0.46) | CASP3SENP7NPC1MEN1KMT2A | |
| SCHEMBL8433630 | 0.82 | TRPV1 (0.36) | CASP3SENP7SENP8SENP6CYP1A2 | |
| Hydrochloric Acid SCHEMBL8438263 | 0.81 | TRPV1 (0.36) | CASP3SENP7SENP8SENP6CYP1A2 | |
| Hydrochloric Acid SCHEMBL8438272 | 0.81 | TRPV1 (0.36) | CASP3SENP7SENP8SENP6CYP1A2 | |
| SCHEMBL8438545 | 0.75 | SMN1; SMN2 (0.49) | NPC1MEN1KMT2ALMNARAB9A | |
| SCHEMBL8434653 | 0.74 | PRSS1 (0.44) | NPC1RAB9ACYP3A4ALDH1A1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |