Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8437871 | 0.99 | NR1H4 (0.44) | NR1H4NOTUMNPC1RAB9ANFKB1 | |
| SCHEMBL8293809 | 0.81 | NOTUM (0.45) | NR1H4NOTUMNPC1RAB9ANFKB1 | |
| SCHEMBL2164730 | 0.81 | NOTUM (0.45) | NR1H4NOTUMNPC1RAB9ANFKB1 | |
| SCHEMBL2164727 | 0.81 | NOTUM (0.45) | NR1H4NOTUMNPC1RAB9ANFKB1 | |
| Hydrochloric Acid SCHEMBL29485544 | 0.80 | NR1H4 (0.52) | NR1H4NOTUMNPC1RAB9ANFKB1 | |
| SCHEMBL8438637 | 0.79 | MAPT (0.36) | NPC1RAB9ASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL6979487 | 0.77 | NR1H4 (0.57) | NR1H4NOTUMNPC1RAB9ANFKB1 | |
| SCHEMBL1609093 | 0.77 | NR1H4 (0.49) | NR1H4NOTUMNPC1RAB9ANFKB1 | |
| SCHEMBL8433420 | 0.76 | IDH1 (0.42) | NPC1RAB9ASMN1; SMN2ALDH1A1S1PR1 | |
| SCHEMBL8437447 | 0.75 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |