Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 6/20 | 0.83 |
| ▸ | THRB | P10828 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | PLG | P00747 | 1/20 | 0.83 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.83 |
| ▸ | RECQL | P46063 | 1/20 | 0.83 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.83 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | BLM | P54132 | 3/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.72 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.72 |
| ▸ | GABRP | O00591 | 1/20 | 0.72 |
| ▸ | GABRD | O14764 | 1/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5376250 | 1.00 | LMNA (0.83) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Succinic Acid SCHEMBL2450010 | 1.00 | LMNA (0.83) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Succinic Acid SCHEMBL8577076 | 1.00 | LMNA (0.83) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Adipic Acid SCHEMBL931429 | 0.91 | LMNA (1.00) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Aminocaproic Acid SCHEMBL21141584 | 0.91 | LMNA (1.00) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Glutarate SCHEMBL2447120 | 0.91 | LMNA (0.89) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| 12-Aminododecanoic Acid SCHEMBL20767098 | 0.91 | LMNA (1.00) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Pimelic Acid SCHEMBL21465298 | 0.91 | LMNA (1.00) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| 12-Aminododecanoic Acid SCHEMBL8973700 | 0.91 | LMNA (1.00) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Adipic Acid SCHEMBL11332689 | 0.91 | LMNA (1.00) | LMNATHRBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859273-A | REACTING POLYAMINO DISUCCINIC ACID WITH IRON COMPOUND AND AMMONIA OR AN ALKALI HYDROXIDE TO FORM BIODEGRADABLE IRON COMPLEX | THE DOW CHEMICAL COMPANY (US) | 1999-01-12 | — | — | US | disclosed |
| US-5741555-A | ELECTROLESS DEPOSITION OF COPPER | THE DOW CHEMICAL COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5569443-A | Method for removing hydrogen sulfide from a gas using polyamino disuccinic acid | THE DOW CHEMICAL COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| WO-1994028464-A1 | SUCCINIC ACID DERIVATIVE DEGRADABLE CHELANTS, USES AND COMPOSITIONS THEREOF | THE DOW CHEMICAL COMPANY (US) | 1994-12-08 | — | — | WO | disclosed |