SCHEMBL8434293

SCHEMBL8434293

O=C(O)Cc1sc(O)nc1O

nearest known ligand 0.68

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.49
ADAMTS5 Q9UNA0 1/20 0.45
PTGDR2 Q9Y5Y4 8/20 0.41
KDM4E B2RXH2 3/20 0.41
POLB P06746 1/20 0.41
CYP1A2 P05177 2/20 0.40
ALDH1A1 P00352 3/20 0.38
TRPM8 Q7Z2W7 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
GAA P10253 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PPARG P37231 1/20 0.35
NCOA2 Q15596 1/20 0.35
NCOA1 Q15788 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15740329 0.81 CYP1A2 (0.56) MAPTADAMTS5PTGDR2KDM4EPOLB
SCHEMBL25834239 0.81 PTGDR2 (0.51) MAPTADAMTS5PTGDR2KDM4EPOLB
SCHEMBL27749017 0.70 PTGDR2 (0.37) MAPTADAMTS5PTGDR2KDM4EPOLB
SCHEMBL1158268 0.63 PTGDR2 (0.40) MAPTADAMTS5PTGDR2KDM4EPOLB
SCHEMBL5026007 0.63 CYP1A2 (0.54) MAPTCYP1A2ALDH1A1MEN1KMT2A
SCHEMBL11150044 0.63 ALDH1A1 (0.53) MAPTPTGDR2KDM4EPOLBCYP1A2
SCHEMBL6739260 0.63 PTGDR2 (0.40) MAPTADAMTS5PTGDR2KDM4EPOLB
SCHEMBL12481306 0.62 CYP1A2 (0.43) MAPTKDM4EPOLBCYP1A2ALDH1A1
SCHEMBL10360134 0.61 PTGDR2 (0.39) MAPTADAMTS5PTGDR2KDM4EPOLB
SCHEMBL13301451 0.61 MEN1 (0.41) MAPTADAMTS5PTGDR2KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3933498-A Fogged, direct positive silver halide emulsions containing a bleach inhibiting compound and a Dmin maintainer compound E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-01-20 US claimed
WO-2023154344-A1 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-17 WO disclosed
EP-2565245-B1 Moisture-proof material NITTO DENKO CORP (JP) 2018-07-25 EP disclosed
CN-103421442-B Moisture-proof material 日东电工株式会社 2017-04-19 CN disclosed
US-9546303-B2 Moisture-proof material NITTO DENKO CORPORATION (JP) 2017-01-17 US disclosed
US-20130337261-A1 MOISTURE-PROOF MATERIAL NITTO DENKO CORPORATION (JP) 2013-12-19 US disclosed
CN-103421442-A Moisture-proof material NITTO DENKO CORP 2013-12-04 CN disclosed
EP-2666836-A2 Moisture-proof material Nitto Denko Corporation (JP) 2013-11-27 EP disclosed
CN-102965042-A Moisture-proof material NITTO DENKO CORP 2013-03-13 CN disclosed
EP-2565245-A2 Moisture-proof material NITTO DENKO CORPORATION (JP) 2013-03-06 EP disclosed
US-20130052461-A1 MOISTURE-PROOF MATERIAL NITTO DENKO CORPORATION (JP) 2013-02-28 US disclosed
US-5891737-A ORTHOGONALLY PROTECTED TRIFUNCTIONAL SCAFFOLDS FOR SOLID PHASE SYNTHESIS OF PEPTIDOMIMETIC COMBINATORIAL LIBRARY ZYMOGENETICS, INC. (US) 1999-04-06 US disclosed
US-5646285-A ORTHOGONALLY PROTECTED COMPOUNDS ZYMOGENETICS, INC. (US) 1997-07-08 US disclosed
WO-1996040732-A1 COMBINATORIAL NON-PEPTIDE LIBRARIES ZYMOGENETICS, INC. (US) 1996-12-19 WO disclosed
US-3933498-A Fogged, direct positive silver halide emulsions containing a bleach inhibiting compound and a Dmin maintainer compound E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-01-20 US disclosed