SCHEMBL8434347

SCHEMBL8434347

CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(OCc3ccccc3)cc1)CC2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.48
ALDH1A1 P00352 3/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
MAPT P10636 2/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
POLB P06746 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
KMT2A Q03164 1/20 0.46
SLC6A7 Q99884 1/20 0.46
NAAA Q02083 1/20 0.45
GRM5 P41594 2/20 0.44
S1PR1 P21453 1/20 0.44
S1PR5 Q9H228 1/20 0.44
EGFR P00533 2/20 0.43
HPGD P15428 4/20 0.43
SMN1; SMN2 Q16637 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8435262 0.99 FFAR1 (0.47) FFAR1ALDH1A1NPC1RAB9AMAPT
SCHEMBL8437838 0.96 FFAR1 (0.48) FFAR1ALDH1A1NPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL8437109 0.95 FFAR1 (0.47) FFAR1ALDH1A1NPC1RAB9AMAPT
SCHEMBL8439233 0.93 FFAR1 (0.48) FFAR1ALDH1A1NPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL8434272 0.92 FFAR1 (0.47) FFAR1ALDH1A1NPC1RAB9AMAPT
SCHEMBL8437842 0.89 FFAR1 (0.48) FFAR1ALDH1A1NPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL8437632 0.88 FFAR1 (0.47) FFAR1ALDH1A1NPC1RAB9AMAPT
SCHEMBL8435271 0.88 HPGD (0.46) ALDH1A1MAPTMEN1CYP3A4CYP2C19
SCHEMBL27464735 0.87 ALDH1A1 (0.44) ALDH1A1MEN1CYP3A4CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL8437544 0.87 HPGD (0.46) ALDH1A1MAPTMEN1CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5998433-A THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-07 US claimed
CN-1160403-A Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-09-24 CN claimed
EP-0785939-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS Takeda Chemical Industries, Ltd. (JP) 1997-07-30 EP claimed
WO-1996011201-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-04-18 WO claimed
US-5998433-A THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-07 US disclosed
CN-1160403-A Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-09-24 CN disclosed
EP-0785939-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS Takeda Chemical Industries, Ltd. (JP) 1997-07-30 EP disclosed
WO-1996011201-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-04-18 WO disclosed