SCHEMBL8435271

SCHEMBL8435271

CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(CCc3ccccc3)cc1)CC2

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 8/20 0.46
ALDH1A1 P00352 4/20 0.46
MTHFD1 P11586 1/20 0.44
MTHFD2 P13995 1/20 0.44
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
LMNA P02545 5/20 0.42
NPSR1 Q6W5P4 1/20 0.42
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
TP53 P04637 1/20 0.41
HTT P42858 1/20 0.41
LSS P48449 1/20 0.40
ESR1 P03372 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
MAPT P10636 1/20 0.39
PDE4B Q07343 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8437544 0.99 HPGD (0.46) HPGDALDH1A1MTHFD1MTHFD2CYP3A4
SCHEMBL27464735 0.92 ALDH1A1 (0.44) HPGDALDH1A1MTHFD1MTHFD2CYP3A4
SCHEMBL8437169 0.90 MEN1 (0.53) HPGDALDH1A1MTHFD1MTHFD2LMNA
SCHEMBL8439848 0.90 ALDH1A1 (0.43) HPGDALDH1A1MTHFD1MTHFD2CYP3A4
Hydrochloric Acid SCHEMBL8804440 0.89 ALDH1A1 (0.43) HPGDALDH1A1MTHFD1MTHFD2CYP3A4
Hydrochloric Acid SCHEMBL8437125 0.89 MEN1 (0.52) HPGDALDH1A1MTHFD1MTHFD2LMNA
Hydrochloric Acid SCHEMBL8439685 0.89 ALDH1A1 (0.43) HPGDALDH1A1MTHFD1MTHFD2CYP3A4
SCHEMBL8439218 0.88 ALDH1A1 (0.42) HPGDALDH1A1MTHFD1MTHFD2CYP3A4
SCHEMBL8434347 0.88 FFAR1 (0.48) HPGDALDH1A1CYP3A4CYP2C19LMNA
SCHEMBL8437838 0.88 FFAR1 (0.48) HPGDALDH1A1CYP3A4CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5998433-A THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-07 US claimed
CN-1160403-A Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-09-24 CN claimed
EP-0785939-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS Takeda Chemical Industries, Ltd. (JP) 1997-07-30 EP claimed
WO-1996011201-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-04-18 WO claimed
US-5998433-A THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-07 US disclosed
CN-1160403-A Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-09-24 CN disclosed
EP-0785939-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS Takeda Chemical Industries, Ltd. (JP) 1997-07-30 EP disclosed
WO-1996011201-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-04-18 WO disclosed