Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 12/20 | 0.49 |
| ▸ | FNTA | P49354 | 3/20 | 0.46 |
| ▸ | FNTB | P49356 | 3/20 | 0.46 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.46 |
| ▸ | ERG | P11308 | 3/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097422 | 1.00 | GPBAR1 (0.49) | GPBAR1FNTAFNTBPGGT1BERG | |
| SCHEMBL8535449 | 0.89 | GPBAR1 (0.48) | GPBAR1FNTAFNTBPGGT1BERG | |
| SCHEMBL8097241 | 0.89 | GPBAR1 (0.48) | GPBAR1FNTAFNTBPGGT1BERG | |
| SCHEMBL8427986 | 0.85 | FNTA (0.53) | GPBAR1FNTAFNTBPGGT1B | |
| SCHEMBL8098229 | 0.85 | FNTA (0.53) | GPBAR1FNTAFNTBPGGT1B | |
| SCHEMBL8097418 | 0.85 | FNTA (0.42) | GPBAR1FNTAFNTBPGGT1BCHRM4 | |
| SCHEMBL7521521 | 0.80 | FNTA (0.44) | FNTAFNTBPGGT1BCYP3A4CYP2D6 | |
| SCHEMBL7453431 | 0.80 | FNTA (0.44) | FNTAFNTBPGGT1BCYP3A4CYP2D6 | |
| SCHEMBL8444169 | 0.79 | FNTA (0.51) | GPBAR1FNTAFNTBPGGT1B | |
| SCHEMBL8097922 | 0.79 | FNTA (0.51) | GPBAR1FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | claimed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | claimed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | claimed |
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| US-5817678-A | IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | disclosed |