Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434681 | 1.00 | NOS3 (0.39) | NOS3NOS1NOS2CTSLCTSK | |
| SCHEMBL8438632 | 0.93 | NOS3 (0.40) | NOS3NOS1NOS2CTSLCTSK | |
| SCHEMBL8438627 | 0.93 | NOS3 (0.40) | NOS3NOS1NOS2CTSLCTSK | |
| SCHEMBL8433814 | 0.85 | ATM (0.41) | CTSLCTSKCTSBCTSSPRSS1 | |
| SCHEMBL8433803 | 0.85 | ATM (0.41) | CTSLCTSKCTSBCTSSPRSS1 | |
| SCHEMBL8434224 | 0.84 | NOS3 (0.42) | NOS3NOS1NOS2CTSLCTSK | |
| SCHEMBL8434220 | 0.84 | NOS3 (0.42) | NOS3NOS1NOS2CTSLCTSK | |
| SCHEMBL8437793 | 0.82 | PRSS1 (0.42) | CTSLCTSKMEN1KMT2ACTSS | |
| SCHEMBL8437789 | 0.82 | PRSS1 (0.42) | CTSLCTSKMEN1KMT2ACTSS | |
| SCHEMBL8438630 | 0.77 | NOS3 (0.41) | NOS3NOS1NOS2CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |