Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8433808 | 0.92 | ATM (0.41) | CTSLATMALOX5TRPM8 | |
| SCHEMBL8434221 | 0.91 | NOS3 (0.43) | NOS3NOS1NOS2CTSLCTSK | |
| SCHEMBL8434685 | 0.91 | NOS3 (0.40) | NOS3NOS1NOS2CTSLCTSK | |
| SCHEMBL8437791 | 0.89 | ATM (0.40) | CTSLCTSKATMPRSS1PRSS2 | |
| SCHEMBL8436495 | 0.84 | HDAC6 (0.42) | CTSLCTSKATMTRPM8 | |
| SCHEMBL8438342 | 0.83 | ATM (0.43) | ATMALOX5TRPM8 | |
| SCHEMBL8434772 | 0.81 | PRSS1 (0.46) | CTSLCTSKATMPRSS1PRSS2 | |
| SCHEMBL8434656 | 0.80 | ATM (0.42) | CTSLCTSKATMPRSS1PRSS2 | |
| SCHEMBL8433075 | 0.80 | ATM (0.45) | CTSLCTSKATMTRPM8 | |
| SCHEMBL8437488 | 0.79 | ATM (0.45) | ATMTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |