Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501739 | 0.91 | EDNRA (0.47) | EDNRAALDH1A1TSHRBRS3 | |
| SCHEMBL8435078 | 0.82 | EDNRA (0.47) | EDNRAAGTR1AGTR2CTSLCTSB | |
| SCHEMBL8432501 | 0.80 | EDNRA (0.49) | EDNRAAGTR1AGTR2SIRT2ALDH1A1 | |
| SCHEMBL8433794 | 0.80 | EDNRA (0.40) | EDNRAAGTR1AGTR2CTSLCTSB | |
| SCHEMBL8432538 | 0.78 | EDNRA (0.40) | EDNRAAGTR1AGTR2CTSLCTSB | |
| SCHEMBL7501757 | 0.76 | EDNRA (0.55) | EDNRABRS3 | |
| SCHEMBL8432726 | 0.76 | EDNRA (0.54) | EDNRAAGTR1AGTR2SIRT2ALDH1A1 | |
| SCHEMBL7496916 | 0.76 | EDNRA (0.54) | EDNRAAGTR1AGTR2BRS3 | |
| SCHEMBL8434730 | 0.75 | EDNRA (0.39) | EDNRAALDH1A1TSHRBRS3 | |
| SCHEMBL8049397 | 0.75 | EDNRA (0.49) | EDNRAAGTR1AGTR2SIRT2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |