Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.39 |
| ▸ | BRS3 | P32247 | 3/20 | 0.35 |
| ▸ | EDNRB | P24530 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501739 | 0.83 | EDNRA (0.47) | EDNRABRS3EDNRBALDH1A1TSHR | |
| SCHEMBL8435081 | 0.83 | EDNRA (0.44) | EDNRABRS3EDNRBALDH1A1 | |
| SCHEMBL8434729 | 0.75 | EDNRA (0.40) | EDNRABRS3ALDH1A1TSHR | |
| SCHEMBL7501755 | 0.73 | EDNRA (0.44) | EDNRABRS3EDNRBALDH1A1 | |
| SCHEMBL7502700 | 0.72 | EDNRA (0.43) | EDNRABRS3EDNRBALDH1A1 | |
| SCHEMBL8435187 | 0.72 | EDNRA (0.44) | EDNRABRS3EDNRBALDH1A1 | |
| SCHEMBL8432517 | 0.69 | EDNRA (0.42) | EDNRAEDNRB | |
| SCHEMBL8434768 | 0.69 | EDNRA (0.52) | EDNRABRS3EDNRBALDH1A1 | |
| SCHEMBL7495951 | 0.69 | EDNRA (0.46) | EDNRABRS3EDNRBALDH1A1 | |
| SCHEMBL6579920 | 0.69 | EDNRA (0.46) | EDNRABRS3EDNRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |