Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438744 | 0.78 | EGFR (0.58) | EGFRPDGFRBPDGFRAKIT | |
| SCHEMBL8434822 | 0.73 | PDGFRB (0.42) | EGFRPDGFRBPDGFRAHDAC8ERBB2 | |
| SCHEMBL7796162 | 0.73 | EGFR (0.63) | EGFRPDGFRBPDGFRA | |
| SCHEMBL3372138 | 0.73 | EGFR (1.00) | EGFRPDGFRBPDGFRANPC1RAB9A | |
| Biphenyl SCHEMBL28023494 | 0.72 | EGFR (0.79) | EGFRPDGFRBPDGFRANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL28032872 | 0.71 | EGFR (0.96) | EGFRPDGFRBPDGFRANPC1RAB9A | |
| SCHEMBL30555608 | 0.70 | PDGFRB (0.65) | EGFRPDGFRBPDGFRAKIT | |
| SCHEMBL7804549 | 0.70 | EGFR (0.51) | EGFRPDGFRBHDAC8ERBB2MAOB | |
| SCHEMBL22498605 | 0.70 | MAOB (0.70) | MAOBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL28188205 | 0.69 | PDGFRB (0.64) | EGFRPDGFRBPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990116-A | USE IN PREVENTION OR TREATMENT OF INFLAMMATORY AND PROLIFERATIVE SKIN DISEASES AND CANCER; COMPOUNDS SUCH AS 6-(2-(2,5-DIMETHOXYPHENYL)ETHYL)-4-ETHYL-QUINAZOLINE | NOVARTIS AG (CH) | 1999-11-23 | — | — | US | disclosed |