Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.63 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438744 | 0.83 | EGFR (0.58) | EGFRFGFR4DHFRPDGFRBPDGFRA | |
| SCHEMBL8438748 | 0.82 | DHFR (0.45) | EGFRDHFRHPGDSPDGFRBPDGFRA | |
| SCHEMBL3372138 | 0.79 | EGFR (1.00) | EGFRFGFR4HPGDSPDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL28032872 | 0.78 | EGFR (0.96) | EGFRFGFR4HPGDSPDGFRBPDGFRA | |
| SCHEMBL7803054 | 0.78 | DHFR (0.42) | EGFRDHFRALDH1A1HPGDMAPK1 | |
| SCHEMBL7796228 | 0.78 | CSF1R (0.42) | EGFRDHFRPDGFRBPDGFRAHAO1 | |
| SCHEMBL7804848 | 0.75 | EGFR (0.68) | EGFRFGFR4DHFRPDGFRBPDGFRA | |
| SCHEMBL7804802 | 0.75 | MTNR1A (0.44) | EGFRDHFRALDH1A1HPGDMAPK1 | |
| SCHEMBL7804088 | 0.75 | ALDH1A1 (0.54) | EGFRALDH1A1HPGDMAPK1 | |
| SCHEMBL7802234 | 0.74 | CYP1A2 (0.43) | EGFRDHFRPDGFRBALDH1A1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815087-B1 | TRISUBSTITUTED PHENYL DERIVATIVES | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-5990116-A | USE IN PREVENTION OR TREATMENT OF INFLAMMATORY AND PROLIFERATIVE SKIN DISEASES AND CANCER; COMPOUNDS SUCH AS 6-(2-(2,5-DIMETHOXYPHENYL)ETHYL)-4-ETHYL-QUINAZOLINE | NOVARTIS AG (CH) | 1999-11-23 | — | — | US | disclosed |
| EP-0815087-A1 | TRISUBSTITUTED PHENYL DERIVATIVES | Novartis AG (CH) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028430-A1 | TRISUBSTITUTED PHENYL DERIVATIVES | NOVARTIS AG (CH) | 1996-09-19 | — | — | WO | disclosed |