Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL8092882 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| Benzoic Acid SCHEMBL592072 | 0.96 | ALDH1A1 (0.65) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL13396749 | 0.92 | ALDH1A1 (0.59) | ALDH1A1KDM4ETDP1TSHRSRD5A2 | |
| Terephthalic Acid SCHEMBL8434830 | 0.91 | ALDH1A1 (0.55) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| Aminobenzoic Acid SCHEMBL5875033 | 0.91 | ALDH1A1 (0.55) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9133941 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9134559 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9460632 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9132279 | 0.90 | TSHR (0.57) | ALDH1A1KDM4ETDP1TSHRHSD17B10 | |
| SCHEMBL9460300 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5933693-A | Electroconductive elastic member and electrophotographic apparatus using same | BRIDGESTONE CORPORATION (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5911099-A | Electroconductiive member and electrophotogrpahic apparatus | BRIDGESTONE CORPORATION (JP) | 1999-06-08 | — | — | US | disclosed |
| US-4255553-A | COMPRISING A COMPOUND HAVING AT LEAST TWO EPOXY GROUPS, A POLYESTER OR ACRYLIC RESIN, AND A QUARTERNARY AMMONIUM CARBOXYLATE AS CATALYST | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1981-03-10 | — | — | US | disclosed |