SCHEMBL8434934

SCHEMBL8434934

CN(C)Cc1cc2c(o1)CN(C(=O)c1ccc(C(=O)c3ccccc3)cc1)CCC2

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.42
MTHFD2 P13995 4/20 0.42
MTHFD1 P11586 2/20 0.42
HPGD P15428 5/20 0.42
ALDH1A1 P00352 3/20 0.40
POLB P06746 1/20 0.39
PLA2G1B P04054 1/20 0.38
ATG4B Q9Y4P1 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TP53 P04637 1/20 0.37
DRD4 P21917 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8440010 0.99 HDAC6 (0.41) HDAC6MTHFD2MTHFD1HPGDALDH1A1
SCHEMBL8439848 0.94 ALDH1A1 (0.43) MTHFD2MTHFD1HPGDALDH1A1POLB
Hydrochloric Acid SCHEMBL8804440 0.93 ALDH1A1 (0.43) MTHFD2MTHFD1HPGDALDH1A1POLB
Hydrochloric Acid SCHEMBL8439685 0.93 ALDH1A1 (0.43) MTHFD2MTHFD1HPGDALDH1A1POLB
SCHEMBL27464735 0.89 ALDH1A1 (0.44) MTHFD2MTHFD1HPGDALDH1A1MEN1
SCHEMBL8436047 0.88 HPGD (0.42) MTHFD2MTHFD1HPGDALDH1A1MEN1
SCHEMBL8439061 0.88 ALDH1A1 (0.43) MTHFD2MTHFD1HPGDALDH1A1POLB
Hydrochloric Acid SCHEMBL8439761 0.87 HPGD (0.42) MTHFD2MTHFD1HPGDALDH1A1MEN1
Hydrochloric Acid SCHEMBL8436197 0.87 ALDH1A1 (0.43) MTHFD2MTHFD1HPGDALDH1A1POLB
SCHEMBL8437222 0.86 HPGD (0.47) MTHFD2MTHFD1HPGDALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5998433-A THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-07 US disclosed
CN-1160403-A Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-09-24 CN disclosed
EP-0785939-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS Takeda Chemical Industries, Ltd. (JP) 1997-07-30 EP disclosed
WO-1996011201-A1 SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-04-18 WO disclosed