SCHEMBL8434944

SCHEMBL8434944

O=[N+]([O-])c1cccc2c(CCl)cccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.67
TDP1 Q9NUW8 3/20 0.67
TSHR P16473 2/20 0.67
NCOA1 Q15788 1/20 0.46
NCOA3 Q9Y6Q9 1/20 0.46
GAA P10253 1/20 0.46
POLB P06746 1/20 0.46
CTSB P07858 2/20 0.46
GPR35 Q9HC97 1/20 0.44
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
KDM4E B2RXH2 2/20 0.42
CYP3A4 P08684 2/20 0.42
ALOX15 P16050 2/20 0.42
NOS1 P29475 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26059158 0.83 TDP1 (0.69) ALDH1A1TDP1TSHRNCOA1NCOA3
SCHEMBL57166 0.82 TDP1 (1.00) ALDH1A1TDP1TSHRNCOA1NCOA3
SCHEMBL29475175 0.82 TDP1 (1.00) ALDH1A1TDP1TSHRNCOA1NCOA3
SCHEMBL30261877 0.80 ALDH1A1 (1.00) ALDH1A1TDP1TSHRHPGDSMN1; SMN2
SCHEMBL69613 0.80 ALDH1A1 (1.00) ALDH1A1TDP1TSHRHPGDSMN1; SMN2
SCHEMBL28093598 0.80 TDP1 (0.95) ALDH1A1TDP1TSHRNCOA1NCOA3
SCHEMBL5604297 0.79 TSHR (0.69) ALDH1A1TDP1TSHRGPR35HPGD
SCHEMBL11693636 0.79 ALDH1A1 (0.69) ALDH1A1TDP1TSHRGPR35HPGD
SCHEMBL18224179 0.79 ALDH1A1 (0.69) ALDH1A1TDP1TSHRGPR35HPGD
SCHEMBL17141360 0.78 ALDH1A1 (0.67) ALDH1A1TDP1TSHRGPR35HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5872129-A REACTING AROMATIC ALPHA-METHYL HALIDES WITH N-ALKYL OR N-ARYLDIETHANOLAMINES TO GIVE QUATERNARY DIOLS AND CONVERTING DIOLS TO HALOGEN OR SULFONATE DERIVATIVES BY TREATING WITH SULFONYL CHLORIDE; ANTITUMOR BLOOD FLOW AGENT AUCKLAND UNISERVICES LIMITED (NZ) 1999-02-16 US disclosed
US-5691371-A ANTITUMOR AND -CARCINOGENIC AGENTS; PRODRUGS BIOREDUCED TO RELEASE A CYTOTOXIN, A MECHLORETHAMINE DERIVATIVE; WATER SOLUBLE AUCKLAND UNISERVICES LIMITED (NZ) 1997-11-25 US disclosed
EP-0700376-A4 NITROBENZYL MUSTARD QUATERNARY SALTS AND THEIR USE AS HYPOXIA-SELECTIVE CYTOTOXIC AGENTS AUCKLAND UNISERVICES LTD (NZ) 1996-05-22 EP disclosed
EP-0700376-A1 NITROBENZYL MUSTARD QUATERNARY SALTS AND THEIR USE AS HYPOXIA-SELECTIVE CYTOTOXIC AGENTS AUCKLAND UNISERVICES LIMITED (NZ) 1996-03-13 EP disclosed
WO-1994027954-A1 NITROBENZYL MUSTARD QUATERNARY SALTS AND THEIR USE AS HYPOXIA-SELECTIVE CYTOTOXIC AGENTS AUCKLAND UNISERVICES LIMITED (NZ) 1994-12-08 WO disclosed
US-4206144-A N,N-Dialkyl-N-aminoalkyl-N-(amino or nitro)phenylalkyl- and N-methyl-N-[3-(amino or nitro)phenoxy-2-hydroxy-1-propyl]-N,N-bis(3-aminopropyl)quaternary ammonium salts STERLING DRUG INC. (US) 1980-06-03 US disclosed
US-4146558-A Azo dyestuff intermediate nitro- or aminobenzenes ring-substituted by a quaternized amine alkyl or amino-alkoxy group STERLING DRUG INC. (US) 1979-03-27 US disclosed
US-4103092-A Water-soluble quaternary ammonium non-heterocyclic azo dyestuffs STERLING DRUG INC. (US) 1978-07-25 US disclosed
US-4065500-A Water-soluble quaternary ammonium azo dyestuffs STERLING DRUG INC. (US) 1977-12-27 US disclosed
US-3996282-A Water-soluble quaternary ammonium dyestuffs STERLING DRUG INC. (US) 1976-12-07 US disclosed
US-3935182-A Water-soluble quaternary ammonium heterocyclic azo dyestuffs STERLING DRUG INC. (US) 1976-01-27 US disclosed