Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441805 | 1.00 | PDK1 (0.42) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8537713 | 1.00 | PDK1 (0.42) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8543375 | 1.00 | PDK1 (0.42) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8588093 | 0.94 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8435956 | 0.94 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8435953 | 0.94 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8438343 | 0.90 | PDK1 (0.38) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL8537550 | 0.89 | MEN1 (0.42) | ALDH1A1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL8537549 | 0.89 | MEN1 (0.42) | ALDH1A1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL8436766 | 0.89 | MEN1 (0.42) | ALDH1A1MAPTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866564-A | STABILITY | SANKYO COMPANY, LIMITED (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0518558-B1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | SANKYO CO (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5712267-A | Carbapenem derivatives, their preparation and their use as antibiotics | SANKYO COMPANY,. LIMITED (JP) | 1998-01-27 | — | — | US | disclosed |
| EP-0518558-A1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | Sankyo Company Limited (JP) | 1992-12-16 | — | — | EP | disclosed |