Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | TOP2A | P11388 | 5/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.47 |
| ▸ | STAT3 | P40763 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10472998 | 0.93 | ADRB2 (0.57) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL29492858 | 0.90 | ADRB2 (0.68) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL2844967 | 0.90 | ADRB2 (0.68) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL10472076 | 0.89 | ADRB2 (0.56) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL5704396 | 0.88 | ADRB2 (0.64) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL28411639 | 0.87 | ADRB2 (0.60) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL4564641 | 0.86 | ADRB2 (0.57) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL7575069 | 0.86 | ADRB2 (0.61) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL10627001 | 0.86 | ADRB2 (0.66) | ADRB2TOP2ATOP2BSTAT3KCNH2 | |
| SCHEMBL9693055 | 0.85 | ADRB2 (0.65) | ADRB2TOP2ATOP2BSTAT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5969141-A | Intermediates for 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarbox ylic acid antibacterial agents | BAYER AKTIENGESELLSCHAFT (DE) | 1999-10-19 | — | — | US | disclosed |
| US-5777181-A | 2, 4, 5-trihalogeno- and 2, 3, 4, 5-tetrahalogenobenzene derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5571812-A | TREATMENT OF INFECTIONS OF GRAMNEGATIVE AND GRAMPOSITIVE BACTERIA | BAYER AKTIENGESELLSCHAFT (DE) | 1996-11-05 | — | — | US | disclosed |
| US-5565614-A | FLUORINATION | BAYER AKTIENGESELLSCHAFT (DE) | 1996-10-15 | — | — | US | disclosed |
| US-5530158-A | CHEMICAL INTERMEDIATE FOR ANTIBACTERIALS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-06-25 | — | — | US | disclosed |
| US-5468861-A | Bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1995-11-21 | — | — | US | disclosed |
| US-5362909-A | Two stage fluorination | BAYER AKTIENGESELLSCHAFT (DE) | 1994-11-08 | — | — | US | disclosed |
| US-5200548-A | Intermediates for bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1993-04-06 | — | — | US | disclosed |
| US-5072038-A | Chemical intermediates for bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-10 | — | — | US | disclosed |
| US-4956465-A | Bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1990-09-11 | — | — | US | disclosed |
| US-4703047-A | 1-Cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents | BAYER AKTIENGESELLSCHAFT (DE) | 1987-10-27 | — | — | US | disclosed |