Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 2/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 4/20 | 0.49 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373911 | 1.00 | ALDH1A1 (0.57) | ALDH1A1ATMELANETRPM8CTSK | |
| SCHEMBL18352556 | 0.86 | HCAR2 (0.52) | ATMELANETRPM8CTSKCTRB1 | |
| SCHEMBL18352579 | 0.86 | HCAR2 (0.52) | ATMELANETRPM8CTSKCTRB1 | |
| SCHEMBL15395673 | 0.84 | ATM (0.54) | ALDH1A1ATMELANETRPM8CTSK | |
| SCHEMBL25465632 | 0.84 | TRPM8 (0.66) | ALDH1A1ATMELANETRPM8CTSK | |
| SCHEMBL15238327 | 0.84 | ATM (0.57) | ATMELANETRPM8CTSKCTRB1 | |
| SCHEMBL13489691 | 0.84 | ATM (0.57) | ATMELANETRPM8CTSKCTRB1 | |
| SCHEMBL2723524 | 0.84 | ATM (0.57) | ATMELANETRPM8CTSKCTRB1 | |
| SCHEMBL5724016 | 0.84 | ATM (0.57) | ATMELANETRPM8CTSKCTRB1 | |
| SCHEMBL12798890 | 0.84 | ATM (0.57) | ATMELANETRPM8CTSKCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |