Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936838 | 0.83 | ABHD6 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL938055 | 0.83 | ABHD6 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL938053 | 0.83 | ABHD6 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL6585428 | 0.82 | EP300 (0.48) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6584883 | 0.82 | EP300 (0.48) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6584627 | 0.81 | CHRNB4 (0.56) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL6583117 | 0.81 | CHRNB4 (0.56) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL7827305 | 0.81 | ALOX5AP (0.47) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL6620281 | 0.81 | ALOX5AP (0.47) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL7371666 | 0.80 | CHRNB2 (0.60) | CHRNB2CHRNB1CHRNB4CHRNA3CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948793-A | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release | ABBOTT LABORATORIES (US) | 1999-09-07 | — | — | US | disclosed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |