Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435630 | 1.00 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8434967 | 0.87 | EDNRA (0.63) | EDNRAAGTR1AGTR2 | |
| SCHEMBL8435201 | 0.85 | EDNRA (0.63) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8521585 | 0.85 | EDNRA (0.61) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8663465 | 0.82 | EDNRA (0.46) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7494119 | 0.82 | EDNRA (0.60) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8434697 | 0.82 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7497895 | 0.82 | EDNRA (0.73) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3837125 | 0.81 | EDNRA (0.70) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7501847 | 0.81 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1082961-C | Novel use and noveld erivatives of imidazole, method for preparing same, novel intermediates thus obtained, medicinal applications of same and pharmaceutical compositions containing same | ROUSSEL UCLAF (FR) | 2002-04-17 | — | — | CN | disclosed |
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |
| CN-1158613-A | New use and new derivatives of imidazole, their preparation, new intermediates obtained, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-09-03 | — | — | CN | disclosed |