Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494119 | 0.90 | EDNRA (0.60) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8434967 | 0.90 | EDNRA (0.63) | EDNRAAGTR1AGTR2 | |
| SCHEMBL8521585 | 0.89 | EDNRA (0.61) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8043446 | 0.89 | EDNRA (0.59) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8434697 | 0.88 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7496869 | 0.85 | EDNRA (0.66) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8435635 | 0.85 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8435630 | 0.85 | EDNRA (0.58) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8046639 | 0.85 | EDNRA (0.65) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7496916 | 0.85 | EDNRA (0.54) | EDNRAAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |