Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.53 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784785 | 0.85 | CD274 (0.53) | CD274PDCD1DPP4 | |
| SCHEMBL3793203 | 0.83 | CD274 (0.69) | CD274PDCD1DPP4PNMTEPHX1 | |
| SCHEMBL12524048 | 0.81 | DPP4 (0.69) | DPP4ABATABL1ABCB1BCR | |
| SCHEMBL16581454 | 0.80 | ABL1 (0.52) | CD274PDCD1ABL1ABCB1BCR | |
| SCHEMBL4941499 | 0.78 | CD274 (0.53) | CD274PDCD1EPHX1 | |
| SCHEMBL30046939 | 0.75 | TRPA1 (0.48) | CD274PDCD1ABL1ABCB1BCR | |
| SCHEMBL1513532 | 0.75 | TRPA1 (0.48) | CD274PDCD1ABL1ABCB1BCR | |
| SCHEMBL3805255 | 0.75 | DPP4 (0.55) | CD274PDCD1DPP4PNMT | |
| SCHEMBL3789280 | 0.74 | HTR7 (0.49) | CD274PDCD1DPP4PNMT | |
| SCHEMBL27989294 | 0.73 | ESR1 (0.46) | CD274PDCD1ABL1ABCB1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966436-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Bayer Aktiengesellschaft (DE) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998037061-A1 | ARYL SULFONAMIDES AND ANALOGUES THEREOF AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-08-27 | — | — | WO | disclosed |