Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8521692 | 0.90 | ALDH1A1 (0.46) | TDP1ALDH1A1MAPTATMHPGD | |
| SCHEMBL8438157 | 0.86 | HTR2C (0.47) | TDP1ALDH1A1MAPTHPGDKCNJ1 | |
| SCHEMBL8435747 | 0.86 | HTR2C (0.47) | TDP1ALDH1A1MAPTHPGDKCNJ1 | |
| SCHEMBL8437972 | 0.86 | HTR2C (0.47) | TDP1ALDH1A1MAPTHPGDKCNJ1 | |
| SCHEMBL4674934 | 0.84 | HTR2C (0.52) | RAB9A | |
| SCHEMBL2929662 | 0.84 | KCNJ1 (0.42) | TDP1ALDH1A1MAPTHPGDKCNJ1 | |
| SCHEMBL8438756 | 0.84 | ALDH1A1 (0.37) | TDP1ALDH1A1MAPTATMHPGD | |
| SCHEMBL8438676 | 0.81 | ALDH1A1 (0.36) | TDP1ALDH1A1MAPTATMHPGD | |
| SCHEMBL1055545 | 0.81 | ITGB2 (0.39) | TDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL1056587 | 0.80 | ITGB2 (0.41) | ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866564-A | STABILITY | SANKYO COMPANY, LIMITED (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0518558-B1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | SANKYO CO (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5712267-A | Carbapenem derivatives, their preparation and their use as antibiotics | SANKYO COMPANY,. LIMITED (JP) | 1998-01-27 | — | — | US | disclosed |
| EP-0518558-A1 | 1-Methylcarbapenem derivatives, their preparation and their use as antibiotics | Sankyo Company Limited (JP) | 1992-12-16 | — | — | EP | disclosed |