Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.67 |
| ▸ | CES2 | O00748 | 5/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 6/20 | 0.48 |
| ▸ | PPARD | Q03181 | 6/20 | 0.48 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21981556 | 0.98 | CES2 (0.68) | CES1CES2GPR84PPARGPPARD | |
| SCHEMBL9074296 | 0.98 | CES2 (0.68) | CES1CES2GPR84PPARGPPARD | |
| SCHEMBL30762095 | 0.98 | CES2 (0.68) | CES1CES2GPR84PPARGPPARD | |
| SCHEMBL24327163 | 0.89 | CES2 (0.58) | CES1CES2GPR84PPARGPPARD | |
| SCHEMBL27634099 | 0.88 | CES1 (0.64) | CES1CES2AKR1B1GPR84PPARG | |
| SCHEMBL11352671 | 0.87 | CES2 (0.50) | CES1CES2AKR1B1GPR84PPARG | |
| SCHEMBL15309037 | 0.86 | CES2 (0.58) | CES1CES2GPR84PPARGPPARD | |
| SCHEMBL7870696 | 0.85 | CES1 (0.62) | CES1CES2AKR1B1ALDH1A1 | |
| SCHEMBL13288871 | 0.85 | GPR84 (0.61) | CES1CES2AKR1B1GPR84PPARG | |
| Potassium Ion SCHEMBL4019143 | 0.83 | CES2 (0.56) | CES1CES2AKR1B1GPR84PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508469-B1 | 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides | DOWELANCO (US) | 1999-03-03 | — | — | EP | claimed |
| US-5493024-A | 1,2-DIARYL-2-PROPEN-1-ONE CHEMICAL INTERMEDIATE COMPOUND | DOWELANCO (US) | 1996-02-20 | — | — | US | claimed |
| EP-0508469-A1 | 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides | DOWELANCO (US) | 1992-10-14 | — | — | EP | claimed |
| US-20230220353-A1 | IN VITRO LIVER ORGANOIDS AND MINI-BILE DUCT MODELS OF BILIARY ARTRESIA AND APPLICATIONS THEREOF | YUE HAI BING (CN) | 2023-07-13 | — | — | US | disclosed |
| EP-0508469-B1 | 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides | DOWELANCO (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5493024-A | 1,2-DIARYL-2-PROPEN-1-ONE CHEMICAL INTERMEDIATE COMPOUND | DOWELANCO (US) | 1996-02-20 | — | — | US | disclosed |
| US-5493024-A | 1,2-DIARYL-2-PROPEN-1-ONE CHEMICAL INTERMEDIATE COMPOUND | DOWELANCO (US) | 1996-02-20 | — | — | US | disclosed |
| US-5250532-A | Moths. termites | DOWELANCO (US) | 1993-10-05 | — | — | US | disclosed |
| US-5250532-A | Moths. termites | DOWELANCO (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0508469-A1 | 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides | DOWELANCO (US) | 1992-10-14 | — | — | EP | disclosed |
| EP-0508469-A1 | 3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides | DOWELANCO (US) | 1992-10-14 | — | — | EP | disclosed |
| US-4038415-A | ENZYME INHIBITORS | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1977-07-26 | — | — | US | disclosed |
| US-4016223-A | Prostaglandin dehydrogenase inhibiting agents | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1977-04-05 | — | — | US | disclosed |