Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8901702 | 0.84 | CHRNA7 (0.45) | CHRNA7HIF1ATRAP1 | |
| Bromide SCHEMBL16197658 | 0.84 | CHRNA7 (0.45) | CHRNA7HIF1ATRAP1 | |
| Bromide SCHEMBL10706995 | 0.84 | CHRNA7 (0.45) | CHRNA7HIF1ATRAP1 | |
| Bromide SCHEMBL6693614 | 0.83 | CHRNA7 (0.43) | CHRNA7HIF1ATRAP1 | |
| Iodide SCHEMBL28884356 | 0.81 | CHRNA7 (0.48) | CHRNA7HIF1ATRAP1 | |
| Iodide SCHEMBL15377774 | 0.81 | CHRNA7 (0.48) | CHRNA7HIF1ATRAP1 | |
| Bromide SCHEMBL52420 | 0.80 | HIF1A (0.70) | CHRNA7HIF1ATRAP1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL2450121 | 0.80 | HIF1A (0.70) | CHRNA7HIF1ATRAP1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL4184421 | 0.80 | HIF1A (0.70) | CHRNA7HIF1ATRAP1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL3391859 | 0.80 | HIF1A (0.70) | CHRNA7HIF1ATRAP1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675130-B1 | Process for the preparation of phosphonium salts | SHINETSU CHEMICAL CO (JP) | 1999-12-29 | — | — | EP | disclosed |
| US-5481040-A | REACTING A PHOSPHINE WITH A CHLORIDE IN THE PRESENCE OF AN ALKALI METAL SALT AND A SOLVENT | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0675130-A2 | Process for the preparation of phosphonium salts | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1995-10-04 | — | — | EP | disclosed |