Bromide

Bromide

SCHEMBL8901702

CC(C)(C)[Si](C)(C)OCCCCCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 8/20 0.45
TRAP1 Q12931 2/20 0.40
HIF1A Q16665 1/20 0.40
DUT P33316 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL10706995 1.00 CHRNA7 (0.45) CHRNA7TRAP1HIF1ADUT
Bromide SCHEMBL16197658 1.00 CHRNA7 (0.45) CHRNA7TRAP1HIF1ADUT
Bromide SCHEMBL6693614 0.98 CHRNA7 (0.43) CHRNA7TRAP1HIF1ADUT
Iodide SCHEMBL28884356 0.97 CHRNA7 (0.48) CHRNA7TRAP1HIF1ADUT
Iodide SCHEMBL15377774 0.97 CHRNA7 (0.48) CHRNA7TRAP1HIF1ADUT
Bromide SCHEMBL1040282 0.94 HIF1A (0.42) CHRNA7TRAP1HIF1ADUT
Bromide SCHEMBL8436730 0.84 CHRNA7 (0.49) CHRNA7TRAP1HIF1A
SCHEMBL31362386 0.79 CHRNA7 (0.43) CHRNA7TRAP1HIF1A
SCHEMBL13527885 0.77 SIGMAR1 (0.44) DUT
Bromide SCHEMBL7471956 0.77 CHRNA7 (0.40) CHRNA7TRAP1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5599837-A 15-DEOXYPROSTAGLANDINS SHIONOGI & CO., LTD. (JP) 1997-02-04 US disclosed
EP-0471856-B1 15-DEOXYPROSTAGLANDIN DERIVATIVE SHIONOGI & CO (JP) 1995-03-22 EP disclosed
US-5292754-A Using 15-deoxyprostaglandin derivative SHIONOGI & CO., LTD. (JP) 1994-03-08 US disclosed
EP-0471856-A1 15-DEOXYPROSTAGLANDIN DERIVATIVE SHIONOGI & CO., LTD. (JP) 1992-02-26 EP disclosed
US-4659516-A ANTIESTROGENS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-04-21 US disclosed
EP-0138504-A2 Steroid derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-04-24 EP disclosed