Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.44 |
| ▸ | GPR183 | P32249 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | QRFPR | Q96P65 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.38 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437891 | 1.00 | LSS (0.44) | LSSGPR183PDE4BPDE4DPOLB | |
| Hydrochloric Acid SCHEMBL8440134 | 0.99 | LSS (0.43) | LSSGPR183PDE4BPDE4DPOLB | |
| Hydrochloric Acid SCHEMBL8440139 | 0.99 | LSS (0.43) | LSSGPR183PDE4BPDE4DPOLB | |
| SCHEMBL8437892 | 0.93 | SNCA (0.42) | LSSGPR183PDE4BPDE4DKCNH2 | |
| SCHEMBL8437886 | 0.93 | SNCA (0.42) | LSSGPR183PDE4BPDE4DKCNH2 | |
| SCHEMBL8439610 | 0.92 | LSS (0.44) | LSSGPR183PDE4BPDE4DPOLB | |
| SCHEMBL8434406 | 0.92 | ALDH1A1 (0.41) | CYP2D6SNCAMTHFD1MTHFD2KMT2A | |
| SCHEMBL8439613 | 0.92 | LSS (0.44) | LSSGPR183PDE4BPDE4DPOLB | |
| SCHEMBL8436361 | 0.92 | ALDH1A1 (0.41) | CYP2D6SNCAMTHFD1MTHFD2KMT2A | |
| SCHEMBL8434410 | 0.92 | ALDH1A1 (0.41) | CYP2D6SNCAMTHFD1MTHFD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998433-A | THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| CN-1160403-A | Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-09-24 | — | — | CN | disclosed |