Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL10949251 | 0.95 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| Acetic Acid SCHEMBL3786910 | 0.95 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| Acetic Acid SCHEMBL7871075 | 0.95 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| Butyltriphenylphosphonium SCHEMBL8437734 | 0.93 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| Benzoic Acid SCHEMBL7871040 | 0.91 | CES2 (0.50) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| Benzoic Acid SCHEMBL7874541 | 0.91 | CES2 (0.50) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| Butyltriphenylphosphonium SCHEMBL328957 | 0.89 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| SCHEMBL7871283 | 0.89 | HIF1A (0.54) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| SCHEMBL7871293 | 0.89 | HIF1A (0.54) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| SCHEMBL29375680 | 0.89 | HIF1A (0.58) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061998-C | Process for producing aromatic polycarbonate | MITSUBISHI CHEM CORP (JP) | 2001-02-14 | — | — | CN | disclosed |
| EP-0703262-B1 | Process for producing aromatic polycarbonate | MITSUBISHI CHEM CORP (JP) | 1999-12-15 | — | — | EP | disclosed |
| US-5578694-A | MELT POLYCONDENSATION OF AROMATIC DIOL AND DIARYL CARBONATE; ESTER INTERCHANGE USING PHOSPHONIUM CATALYST | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-11-26 | — | — | US | disclosed |
| CN-1127265-A | Process for producing aromatic polycarbonate | MITSUBISHI CHEM CORP (JP) | 1996-07-24 | — | — | CN | disclosed |
| EP-0703262-A2 | Process for producing aromatic polycarbonate | Mitsubishi Chemical Corporation (JP) | 1996-03-27 | — | — | EP | disclosed |