Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 1/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20971523 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL8772526 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL8438266 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL8522255 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL8442091 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL27479451 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL8439673 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL20971533 | 1.00 | PLAAT3 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL8772503 | 0.94 | TRPV1 (0.48) | LMNAL3MBTL1ALDH1A1TRPV1ASAH1 | |
| SCHEMBL8442084 | 0.94 | TRPV1 (0.48) | LMNAL3MBTL1ALDH1A1TRPV1ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210236500-A1 | INHIBITION OF AUTOPHAGY USING PHOSPHOLIPASE A2 INHIBITORS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-08-05 | — | — | US | claimed |
| US-20190142835-A1 | INHIBITION OF AUTOPHAGY USING PHOSPHOLIPASE A2 INHIBITORS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2019-05-16 | — | — | US | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| US-20210236500-A1 | INHIBITION OF AUTOPHAGY USING PHOSPHOLIPASE A2 INHIBITORS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-20190142835-A1 | INHIBITION OF AUTOPHAGY USING PHOSPHOLIPASE A2 INHIBITORS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2019-05-16 | — | — | US | disclosed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| CN-1175246-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |