Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8437910 | 0.99 | CHRNB2 (0.63) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8435051 | 0.91 | CHRNB4 (0.66) | CHRNB2CHRNA4 | |
| SCHEMBL8440255 | 0.91 | CHRNB4 (0.66) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7455989 | 0.89 | CHRNB4 (0.64) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7411399 | 0.89 | CHRNB4 (0.64) | CHRNB2CHRNA4 | |
| SCHEMBL4111623 | 0.81 | CHRNB2 (0.68) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| SCHEMBL7411369 | 0.81 | CHRNB2 (0.68) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| SCHEMBL12557242 | 0.81 | CHRNB2 (0.68) | CHRNB2CHRNA4KDM4ECYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL30785448 | 0.81 | KDM1A (0.53) | CHRNB2CHRNA4CHRNA6 | |
| Hydrochloric Acid SCHEMBL27159065 | 0.81 | KDM1A (0.53) | CHRNB2CHRNA4CHRNA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | claimed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |