Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.66 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.66 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.56 |
| ▸ | CHRNG | P07510 | 1/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.56 |
| ▸ | CHRND | Q07001 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435051 | 1.00 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 | |
| Hydrochloric Acid SCHEMBL7455989 | 0.99 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 | |
| Hydrochloric Acid SCHEMBL7411399 | 0.99 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 | |
| SCHEMBL8438398 | 0.91 | CHRNB2 (0.64) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL8437910 | 0.89 | CHRNB2 (0.63) | CHRNB2CHRNA4 | |
| SCHEMBL14004895 | 0.87 | CHRNB4 (0.70) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 | |
| SCHEMBL17676942 | 0.85 | LTA4H (0.63) | CHRNB4CHRNA3LTA4H | |
| SCHEMBL12996857 | 0.85 | LTA4H (0.63) | CHRNB4CHRNA3LTA4H | |
| SCHEMBL12996852 | 0.85 | LTA4H (0.63) | CHRNB4CHRNA3LTA4H | |
| SCHEMBL7409154 | 0.82 | CHRNB4 (0.71) | CHRNB4CHRNA3CHRNB2CHRNA4AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | claimed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |
| EP-0846114-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996040682-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1996-12-19 | — | — | WO | disclosed |