Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443487 | 0.93 | KMT2A (0.48) | PLA2G7TSHRKDM4EALDH1A1TDP1 | |
| SCHEMBL8094721 | 0.89 | PLA2G7 (0.43) | PLA2G7TSHRKDM4EALDH1A1TDP1 | |
| SCHEMBL8440358 | 0.87 | PLA2G7 (0.44) | PLA2G7KDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL27495124 | 0.86 | TRPV1 (0.50) | TSHRALDH1A1TRPV1KMT2ANAMPT | |
| SCHEMBL8441268 | 0.86 | TRPV1 (0.50) | TSHRALDH1A1TRPV1KMT2ANAMPT | |
| SCHEMBL8440280 | 0.86 | TRPV1 (0.50) | TSHRALDH1A1TRPV1KMT2ANAMPT | |
| SCHEMBL27476952 | 0.86 | TRPV1 (0.50) | TSHRALDH1A1TRPV1KMT2ANAMPT | |
| SCHEMBL8440276 | 0.86 | TRPV1 (0.50) | TSHRALDH1A1TRPV1KMT2ANAMPT | |
| SCHEMBL8094761 | 0.86 | TSHR (0.42) | PLA2G7TSHRKDM4EALDH1A1TDP1 | |
| SCHEMBL8440371 | 0.86 | PLA2G7 (0.40) | PLA2G7TSHRKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |