Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 7/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 7/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ATP4A | P20648 | 1/20 | 0.30 |
| ▸ | ATP4B | P51164 | 1/20 | 0.30 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.30 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436369 | 0.92 | SLC6A2 (0.37) | LATS1LATS2SLC6A2BRAFMAP3K7 | |
| SCHEMBL8440769 | 0.90 | LATS1 (0.38) | LATS1LATS2SLC6A2MAPTMAPK1 | |
| SCHEMBL8038900 | 0.87 | SLC6A2 (0.41) | LATS1LATS2SLC6A2MAPTMAPK1 | |
| SCHEMBL8435887 | 0.86 | LATS1 (0.38) | LATS1LATS2BRAFMAP3K7TAB1 | |
| Hydrochloric Acid SCHEMBL8039092 | 0.86 | SLC6A2 (0.40) | SLC6A2MAPTMAPK1NPSR1KDM4E | |
| SCHEMBL8050077 | 0.83 | MAPT (0.33) | LATS1LATS2SLC6A2MAPTMAPK1 | |
| SCHEMBL8039432 | 0.83 | SLC6A2 (0.37) | LATS1LATS2SLC6A2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL9425165 | 0.82 | SLC6A2 (0.37) | LATS1LATS2SLC6A2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL8056275 | 0.82 | MAPT (0.33) | LATS1LATS2SLC6A2MAPTMAPK1 | |
| SCHEMBL8438931 | 0.81 | CYP2A6 (0.41) | LATS1LATS2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856335-A | GLYCINE PARTIAL AGONISTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| EP-0581106-B1 | Substituted aminothienopyridines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5519032-A | ANTIDEPRESSANTS, ANXIOLYTICS, ANTIEMETICS, ANTIPSYCHOTIC | HOECHST MARION ROUSSEL INC. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0581106-A1 | Substituted aminothienopyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5252581-A | Modulators of neurotransmitters | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |