Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11460980 | 0.86 | L3MBTL1 (0.49) | ITGB1ITGA5L3MBTL1TSHRPOLB | |
| SCHEMBL8441054 | 0.83 | PDPK1 (0.49) | PDPK1GRIN1GRIN2BKMT2ASLC6A9 | |
| SCHEMBL8442860 | 0.82 | HMOX1 (0.42) | ITGB1ITGA5FFAR1L3MBTL1POLB | |
| SCHEMBL8438346 | 0.82 | HMOX1 (0.42) | ITGB1ITGA5FFAR1L3MBTL1POLB | |
| SCHEMBL8438341 | 0.82 | HMOX1 (0.42) | ITGB1ITGA5FFAR1L3MBTL1POLB | |
| SCHEMBL8442219 | 0.80 | CYP2C19 (0.40) | SIGMAR1ITGB1ITGA5L3MBTL1TSHR | |
| SCHEMBL8374671 | 0.80 | CYP2C19 (0.40) | SIGMAR1ITGB1ITGA5L3MBTL1TSHR | |
| SCHEMBL8438654 | 0.80 | CYP2C19 (0.40) | SIGMAR1ITGB1ITGA5L3MBTL1TSHR | |
| SCHEMBL8443346 | 0.78 | DDB1 (0.41) | L3MBTL1POLBKMT2A | |
| SCHEMBL8440076 | 0.77 | PDE4B (0.42) | CA12CA9L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |