Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PAM | P19021 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17386357 | 0.84 | CYP3A4 (0.50) | TRPV1CYP3A4NPSR1PKMSMN1; SMN2 | |
| SCHEMBL8301034 | 0.82 | SNCA (0.49) | TRPV1CYP3A4SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL18996987 | 0.80 | ALDH1A1 (0.45) | TRPV1CYP3A4NPSR1PKMSMN1; SMN2 | |
| SCHEMBL27367107 | 0.80 | KMT2A (0.49) | TRPV1CYP3A4NPSR1PKMSMN1; SMN2 | |
| SCHEMBL29620611 | 0.79 | CYP3A4 (0.46) | TRPV1CYP3A4NPSR1PKMSMN1; SMN2 | |
| SCHEMBL5687587 | 0.78 | CA2 (0.47) | TRPV1CYP3A4NPSR1PKMSMN1; SMN2 | |
| SCHEMBL9471247 | 0.77 | TRPV1 (0.59) | TRPV1CYP3A4SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL29034764 | 0.76 | CYP3A4 (0.43) | TRPV1CYP3A4NPSR1PKMSMN1; SMN2 | |
| SCHEMBL5688510 | 0.76 | ALDH1A1 (0.47) | CYP3A4NPSR1SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL5322788 | 0.76 | SMN1; SMN2 (0.53) | CYP3A4NPSR1PKMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |