Sugi Predict

Sugi Predict / Compounds / SCHEMBL8439743

SCHEMBL8439743

SCHEMBL8439743

CC1=CC(=O)N(c2cc(C(=O)O)cc(N3C(=O)C=C(C)C3=O)c2)C1=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NSD2 O96028 1/20 0.58
▸ G6PD P11413 1/20 0.58
▸ KEAP1 Q14145 1/20 0.58
▸ NFE2L2 Q16236 1/20 0.58
▸ NR4A1 P22736 2/20 0.43
▸ TPMT P51580 1/20 0.39
▸ CA12 O43570 3/20 0.39
▸ CA1 P00915 3/20 0.39
▸ CA9 Q16790 3/20 0.39
▸ TYMS P04818 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.37
▸ DDAH1 O94760 1/20 0.37
▸ KDM4E B2RXH2 3/20 0.37
▸ POLB P06746 2/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ TDP1 Q9NUW8 2/20 0.37
▸ MEN1 O00255 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22152298 0.86 NSD2 (0.41) NSD2G6PDKEAP1NFE2L2POLB
SCHEMBL9246650 0.84 TYMS (0.57) NR4A1TYMSKDM4EPOLBL3MBTL1
SCHEMBL8442000 0.83 DDAH1 (0.58) CA12CA1CA9NPSR1DDAH1
SCHEMBL10007017 0.81 XPO1 (0.38) NSD2G6PDKEAP1NFE2L2NPSR1
SCHEMBL8884854 0.80 CCR6 (0.35) NSD2G6PDKEAP1NFE2L2NPSR1
SCHEMBL8885075 0.80 HSP90AA1 (0.52) NPSR1L3MBTL1KMT2AHTTSMN1; SMN2
SCHEMBL22152332 0.79 NSD2 (0.58) NSD2G6PDKEAP1NFE2L2NR4A1
SCHEMBL24939798 0.79 TPMT (0.43) NSD2G6PDKEAP1NFE2L2NR4A1
SCHEMBL8465438 0.78 TYMS (0.51) NR4A1CA12CA1CA9TYMS
SCHEMBL8885538 0.78 TSHR (0.39) ALDH1A1KMT2AMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9701667-B2 Coumarin-based fluorogenic agents and uses thereof for specific protein labelling UNIVERSITY OF OTTAWA (CA) 2017-07-11 — — US disclosed
US-9701667-B2 Coumarin-based fluorogenic agents and uses thereof for specific protein labelling UNIVERSITY OF OTTAWA (CA) 2017-07-11 — — US disclosed
US-9701667-B2 Coumarin-based fluorogenic agents and uses thereof for specific protein labelling UNIVERSITY OF OTTAWA (CA) 2017-07-11 — — US disclosed
US-20150316557-A1 COUMARIN-BASED FLUOROGENIC AGENTS AND USES THEREOF FOR SPECIFIC PROTEIN LABELLING UNIVERSITY OF OTTAWA (CA) 2015-11-05 — — US disclosed
US-20150316557-A1 COUMARIN-BASED FLUOROGENIC AGENTS AND USES THEREOF FOR SPECIFIC PROTEIN LABELLING UNIVERSITY OF OTTAWA (CA) 2015-11-05 — — US disclosed
US-20150316557-A1 COUMARIN-BASED FLUOROGENIC AGENTS AND USES THEREOF FOR SPECIFIC PROTEIN LABELLING UNIVERSITY OF OTTAWA (CA) 2015-11-05 — — US disclosed
US-9006459-B2 Fluorescent markers and use thereof for labeling specific protein targets UNIVERSITY OF OTTAWA (CA) 2015-04-14 — — US disclosed
US-9006459-B2 Fluorescent markers and use thereof for labeling specific protein targets UNIVERSITY OF OTTAWA (CA) 2015-04-14 — — US disclosed
US-9006459-B2 Fluorescent markers and use thereof for labeling specific protein targets UNIVERSITY OF OTTAWA (CA) 2015-04-14 — — US disclosed
US-20150004712-A1 FLUORESCENT MARKERS AND USE THEREOF FOR LABELING SPECIFIC PROTEIN TARGETS UNIVERSITY OF OTTAWA (CA) 2015-01-01 — — US disclosed
US-8835641-B2 Fluorescent markers and use thereof for labeling specific protein targets UNIVERSITY OF OTTAWA (CA) 2014-09-16 — — US disclosed
US-20120171665-A1 FLUORESCENT MARKERS AND USE THEREOF FOR LABELING SPECIFIC PROTEIN TARGETS UNIVERSITE DE MONTREAL (CA) 2012-07-05 — — US disclosed
US-20120171665-A1 FLUORESCENT MARKERS AND USE THEREOF FOR LABELING SPECIFIC PROTEIN TARGETS UNIVERSITE DE MONTREAL (CA) 2012-07-05 — — US disclosed
US-20120171665-A1 FLUORESCENT MARKERS AND USE THEREOF FOR LABELING SPECIFIC PROTEIN TARGETS UNIVERSITE DE MONTREAL (CA) 2012-07-05 — — US disclosed
EP-0495544-B1 Process for the synthesis of citraconimides AKZO NOBEL NV (NL) 1999-04-07 — — EP disclosed
US-5610240-A CITRACONIC IMIDES AKZO NOBEL NV (NL) 1997-03-11 — — US disclosed
EP-0555288-B1 ANTI-REVERSION COAGENTS FOR RUBBER VULCANIZATION AKZO NOBEL NV (NL) 1996-06-19 — — EP disclosed
US-5426155-A Adjuvants which prevent loss of crosslinking in vulcanized rubbers AKZO NOBEL N.V. (NL) 1995-06-20 — — US disclosed
EP-0640114-A1 SULFUR-VULCANIZED RUBBER COMPOSITION Akzo Nobel N.V. (NL) 1995-03-01 — — EP disclosed
WO-1993023467-A1 SULFUR-VULCANIZED RUBBER COMPOSITION AKZO NOBEL N.V. (NL) 1993-11-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120171665-A1 FLUORESCENT MARKERS AND USE THEREOF FOR LABELING SPECIFIC PROTEIN TARGETS HNRNPH1, HNRNPH3, HNRNPC NSD2 3006/4885G6PD 1375/4885KEAP1 697/4885
US-20150004712-A1 FLUORESCENT MARKERS AND USE THEREOF FOR LABELING SPECIFIC PROTEIN TARGETS HNRNPH1, HNRNPH3, HNRNPC NSD2 3006/4885G6PD 1375/4885KEAP1 697/4885
US-20150316557-A1 COUMARIN-BASED FLUOROGENIC AGENTS AND USES THEREOF FOR SPECIFIC PROTEIN LABELLING PFDN1, PFDN6, CDC73 NSD2 4404/4885G6PD 522/4885KEAP1 434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.