SCHEMBL8442000

SCHEMBL8442000

CC1=CC(=O)N(c2ccc(C(=O)O)cc2)C1=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDAH1 O94760 1/20 0.58
CA9 Q16790 10/20 0.53
CA12 O43570 9/20 0.53
CA1 P00915 8/20 0.53
CA2 P00918 3/20 0.53
SCN2A Q99250 1/20 0.53
ALDH1A1 P00352 4/20 0.49
KDM4E B2RXH2 3/20 0.49
MAPT P10636 2/20 0.49
KMT2A Q03164 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
POLB P06746 2/20 0.49
MEN1 O00255 1/20 0.49
HPGD P15428 1/20 0.49
APEX1 P27695 1/20 0.49
RXFP1 Q9HBX9 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
PPARA Q07869 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.44
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465438 0.87 TYMS (0.51) DDAH1CA9CA12CA1CA2
SCHEMBL9064941 0.86 KMT2A (0.46) DDAH1CA9CA12CA1CA2
SCHEMBL94147 0.85 MGLL (0.46) KMT2ATDP1MEN1NPSR1
SCHEMBL8439743 0.83 NSD2 (0.58) DDAH1CA9CA12CA1CA2
SCHEMBL22601779 0.82 MEN1 (0.38) DDAH1CA9CA12CA1CA2
SCHEMBL11251677 0.81 CA9 (0.39) DDAH1CA9CA12CA1CA2
SCHEMBL24938793 0.81 NPSR1 (0.46) DDAH1CA9CA12CA1SCN2A
SCHEMBL9246650 0.81 TYMS (0.57) ALDH1A1KDM4EMAPTKMT2ATDP1
SCHEMBL8443563 0.80 MGLL (0.53) ALDH1A1KDM4EMAPTKMT2ATDP1
SCHEMBL13477928 0.80 KMT2A (0.50) ALDH1A1MAPTKMT2ATDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0336856-B1 WITH MALEIMIDE GROUPS FUNCTIONALIZED AROMATIC POLYAMIDEIMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR PREPARING CROSS-LINKED POLYMERS CIBA-GEIGY AG (CH) 1993-03-03 EP claimed
US-4927900-A Aromatic polyamidoimides having maleimido end groups RHONE-POULENC CHIMIE (FR) 1990-05-22 US claimed
US-20230022129-A1 RESIST MATERIAL AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-01-26 US disclosed
EP-0495544-B1 Process for the synthesis of citraconimides AKZO NOBEL NV (NL) 1999-04-07 EP disclosed
WO-1997003962-A1 IMIDO PERESTERS AS INITIATORS OF POLYMERIZATION PROCESSES AKZO NOBEL N.V. (NL) 1997-02-06 WO disclosed
US-5523360-A IMPROVES MELT-FLOW PROPERTIES AKZO NOBEL N. V. (NL) 1996-06-04 US disclosed
US-5470920-A Impregnating solutions based on at least one reactive thermoplastic poly (imide-amide) oligomer and a coreactant, which can be used especially for the production of preimpregnated intermediate articles CIBA-GEIGY CORPORATION (US) 1995-11-28 US disclosed
EP-0648240-A1 PROCESS FOR THE MODIFICATION OF POLYPHENYLENE ETHER RESIN COMPOSITIONS Akzo Nobel N.V. (NL) 1995-04-19 EP disclosed
EP-0495545-B1 Citraconimide (co)polymers and curing with anionic catalyst AKZO NOBEL NV (NL) 1994-12-28 EP disclosed
WO-1994001485-A1 PROCESS FOR THE MODIFICATION OF POLYPHENYLENE ETHER RESIN COMPOSITIONS AKZO NOBEL N.V. (NL) 1994-01-20 WO disclosed
US-5221717-A CITRACONIMIDE (CO)POLYMERS AND CURING WITH ANIONIC CATALYST AKZO N.V. (NL) 1993-06-22 US disclosed
EP-0495545-A1 Citraconimide (co)polymers and curing with anionic catalyst Akzo Nobel N.V. (NL) 1992-07-22 EP disclosed
US-4927900-A Aromatic polyamidoimides having maleimido end groups RHONE-POULENC CHIMIE (FR) 1990-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230022129-A1 RESIST MATERIAL AND PATTERNING PROCESS GFER, LBR, PCNA DDAH1 93/4885CA9 127/4885CA12 442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.