Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PNLIP | P16233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442624 | 0.89 | MCL1 (0.45) | MCL1BCL2L1 | |
| SCHEMBL8439756 | 0.88 | POLB (0.47) | MCL1BCL2L1 | |
| SCHEMBL8059436 | 0.88 | NR1H4 (0.46) | — | |
| SCHEMBL8440231 | 0.87 | CYP1A2 (0.43) | — | |
| SCHEMBL8438806 | 0.86 | PTGER4 (0.47) | — | |
| SCHEMBL8438984 | 0.85 | TTR (0.51) | MCL1BCL2L1 | |
| SCHEMBL8440193 | 0.85 | MCL1 (0.42) | MCL1CNR2BCL2L1 | |
| SCHEMBL8441330 | 0.84 | KCNQ3 (0.42) | — | |
| SCHEMBL8438364 | 0.83 | SLC9A1 (0.61) | — | |
| SCHEMBL8441138 | 0.81 | CASP1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708088-B1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5700839-A | ANTIARRYTHMIA AGENTS; ACT AS INHIBITORS OF THE CELLULAR NA+/H+ ANTIPORTER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| EP-0708088-A1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1996-04-24 | — | — | EP | disclosed |