Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 11/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.46 |
| ▸ | MAP1LC3A | Q9H492 | 2/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438210 | 0.87 | TSHR (0.48) | ESR2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8441466 | 0.80 | ESR2 (0.49) | ESR2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL15413700 | 0.72 | ESR2 (0.57) | ESR2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14445538 | 0.71 | TOP1 (0.51) | KDM4EALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL8439795 | 0.70 | LRRK2 (0.52) | KDM4EALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL9204225 | 0.69 | CA12 (0.51) | EGFRALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL6828242 | 0.69 | ESR2 (0.89) | ESR2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6825403 | 0.69 | ESR2 (1.00) | ESR2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL15154234 | 0.68 | MEN1 (0.77) | EGFRKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL19019872 | 0.67 | MAP1LC3B (0.67) | ESR2MAP1LC3BMAP1LC3AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985912-A | COUMARONE COMPOUNDS AS BACTERICIDES | PFIZER INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5624951-A | 4-hydroxy coumarin derivatives with antibacterial activity | PFIZER INC. (US) | 1997-04-29 | — | — | US | disclosed |