Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 14/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 8/20 | 0.46 |
| ▸ | SHBG | P04278 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.43 |
| ▸ | MAP1LC3A | Q9H492 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439784 | 0.80 | ESR2 (0.52) | ESR2GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8438210 | 0.76 | TSHR (0.48) | ESR2GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15413700 | 0.73 | ESR2 (0.57) | ESR2GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27778792 | 0.68 | HTT (0.53) | GAAKDM4EALDH1A1MEN1NPC1 | |
| SCHEMBL12469832 | 0.68 | MEN1 (0.59) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL9207445 | 0.68 | CA12 (0.58) | GAAKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6825266 | 0.67 | ESR2 (1.00) | ESR2GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9259933 | 0.67 | ESR2 (0.60) | ESR2GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3766383 | 0.66 | KDM4E (0.74) | ESR2GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15413701 | 0.66 | ESR2 (0.62) | ESR2GAAKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985912-A | COUMARONE COMPOUNDS AS BACTERICIDES | PFIZER INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5624951-A | 4-hydroxy coumarin derivatives with antibacterial activity | PFIZER INC. (US) | 1997-04-29 | — | — | US | disclosed |