Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SGMS1 | Q86VZ5 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441528 | 0.86 | TSHR (0.49) | TSHRHSP90AA1HSP90AB1PDK1PDK2 | |
| SCHEMBL7918882 | 0.83 | TBXA2R (0.59) | TSHRTBXA2RTBXAS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11379516 | 0.82 | TBXA2R (0.74) | TSHRTBXA2RTBXAS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7918951 | 0.82 | TBXA2R (0.57) | TSHRTBXA2RTBXAS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9765332 | 0.81 | SMN1; SMN2 (0.58) | TSHRHSP90AA1HSP90AB1PDK1PDK2 | |
| SCHEMBL11363199 | 0.80 | TSHR (0.75) | TSHRTBXA2RTBXAS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9510518 | 0.79 | SMN1; SMN2 (0.58) | TSHRHSP90AA1HSP90AB1PDK1PDK2 | |
| SCHEMBL9777951 | 0.79 | SMN1; SMN2 (0.57) | TSHRHSP90AA1HSP90AB1PDK1PDK2 | |
| SCHEMBL7921088 | 0.78 | ALDH1A1 (0.63) | TSHRTBXA2RTBXAS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9765259 | 0.77 | GAA (0.53) | TSHRSMN1; SMN2ALDH1A1TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955505-A | TREATING NERVE DEGENERATIVE DISORDERS | NIPPON SUISAN KAISHA, LTD. (JP) | 1999-09-21 | — | — | US | disclosed |