Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440805 | 0.94 | MAPK1 (0.42) | TMEM97SIGMAR1ALDH1A1LMNATSHR | |
| SCHEMBL8440765 | 0.89 | MAPK1 (0.45) | ALDH1A1LMNACYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL8439277 | 0.85 | PDE4B (0.43) | TMEM97SIGMAR1ALDH1A1MAPK1RAB9A | |
| SCHEMBL8444315 | 0.81 | CA12 (0.42) | ALDH1A1LMNARAB9ANFKB1SMN1; SMN2 | |
| SCHEMBL7995581 | 0.81 | MCHR1 (0.46) | TMEM97SIGMAR1ALDH1A1LMNASLC22A1 | |
| Hydrochloric Acid SCHEMBL8817606 | 0.79 | HRH3 (0.40) | CYP2D6ACHEPMP22CYP3A4SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8440407 | 0.78 | SMN1; SMN2 (0.52) | ALDH1A1LMNAHTR4SMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL8440293 | 0.78 | APP (0.53) | ALDH1A1LMNACYP1A2CYP2D6HTR4 | |
| SCHEMBL8440888 | 0.77 | LMNA (0.53) | ALDH1A1LMNAKCNH2CYP1A2CYP2D6 | |
| SCHEMBL8441395 | 0.76 | DAO (0.40) | ALDH1A1LMNATSHRRAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968985-A | INHIBITORS OF SODIUM ION/HYDROGEN ION EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0773927-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004241-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |