Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442243 | 0.94 | TRPV1 (0.49) | TRPV1KMT2AFKBP1AALDH1A1POLB | |
| SCHEMBL8522522 | 0.91 | MEN1 (0.47) | TRPV1KMT2ATP53FKBP1AALDH1A1 | |
| SCHEMBL8521282 | 0.91 | MEN1 (0.47) | TRPV1KMT2ATP53FKBP1AALDH1A1 | |
| SCHEMBL8521285 | 0.91 | MEN1 (0.47) | TRPV1KMT2ATP53FKBP1AALDH1A1 | |
| SCHEMBL8442958 | 0.91 | MAPT (0.47) | TRPV1RAB9AKMT2AFKBP1APOLB | |
| SCHEMBL8549758 | 0.89 | TRPV1 (0.44) | TRPV1KMT2AFKBP1AALDH1A1POLB | |
| SCHEMBL8554153 | 0.87 | HPGD (0.46) | FKBP1AALDH1A1POLBLMNAHPGD | |
| SCHEMBL8443146 | 0.86 | LMNA (0.41) | TRPV1TP53FKBP1AALDH1A1POLB | |
| SCHEMBL8438725 | 0.86 | TRPV1 (0.41) | TRPV1KMT2ATP53FKBP1AALDH1A1 | |
| SCHEMBL8104169 | 0.85 | TRPV1 (0.50) | TRPV1KMT2AALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |